Biography
I've long been interested in how protein-protein interactions shape cell physiology. I performed my graduate work in the lab of Dr. Tania A. Baker, where I studied adaptor-mediated regulated of proteolysis in bacteria. I then performed postdoctoral research in Dr. Sean Crosson's lab, where I studied the regulation of two-component signaling systems in Caulobacter crescentus. These experiences shaped me as a researcher and allowed me to explore my interest in teaching undergraduates. I joined the faculty at Holy Cross in the fall of 2024 and I'm extremely excited to work with Holy Cross students in the classroom and the lab!
Courses
- Biochemistry 1
- Biochemistry 2
- Biochemistry 2 Lab
Publications
Stein, B., Fiebig, A., & Crosson, S. (2021). The ChvG-ChvI and NtrY-NtrX Two-Component Systems Coordinately Regulate Growth of Caulobacter crescentus. Journal of Bacteriology, 203(17), e0019921. https://doi.org/10.1128/JB.00199-21
Stein, B., Fiebig, A., & Crosson, S. (2020). Feedback Control of a Two-Component Signaling System by an Fe-S-Binding Receiver Domain. MBio, 11(2). https://doi.org/10.1128/mBio.03383-19
Tien, M. Z., Stein, B., & Crosson, S. (2018). Coherent Feedforward Regulation of Gene Expression by Caulobacter σT and GsrN during Hyperosmotic Stress. Journal of Bacteriology, 200(19). https://doi.org/10.1128/JB.00349-18
Olivares, A. O., Kotamarthi, H. C., Stein, B., Sauer, R. T., & Baker, T. A. (2017). Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines. Proceedings of the National Academy of Sciences of the United States of America, 114(31), E6306–E6313. https://doi.org/10.1073/pnas.1707794114
Stein, B., Grant, R. A., Sauer, R. T., & Baker, T. A. (2016). Structural Basis of an N-Degron Adaptor with More Stringent Specificity. Structure (London, England : 1993), 24(2), 232–242. https://doi.org/10.1016/j.str.2015.12.008
Choy, M. S., Hieke, M., Kumar, G. S., Lewis, G. R., Gonzalez-DeWhitt, K. R., Kessler, R. P., Stein, B., Hessenberger, M., Nairn, A. C., Peti, W., & Page, R. (2014). Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Proceedings of the National Academy of Sciences of the United States of America, 111(11), 4097–4102. https://doi.org/10.1073/pnas.1317395111